The Golgi and the centrosome: building a functional partnership
نویسندگان
چکیده
The mammalian Golgi apparatus is characterized by a ribbon-like organization adjacent to the centrosome during interphase and extensive fragmentation and dispersal away from the centrosome during mitosis. It is not clear whether this dynamic association between the Golgi and centrosome is of functional significance. We discuss recent findings indicating that the Golgi-centrosome relationship may be important for directional protein transport and centrosome positioning, which are both required for cell polarization. We also summarize our current knowledge of the link between Golgi organization and cell cycle progression.
منابع مشابه
The mammalian Golgi apparatus is characterized by a ribbon-like organization adjacent to the centrosome during interphase and extensive fragmentation and dispersal away
Correspondence to Christine Sütterlin: [email protected]; or Antonino Colanzi: [email protected] Abbreviation used in this paper: -TuRC, -tubulin ring complex. Introduction The Golgi apparatus plays a central role in the secretory pathway. Newly synthesized proteins are transported from the ER to the Golgi, where they are posttranslationally modified. They are sorted into carriers for delivery ...
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